Capabilities

Modeling Infection and Immune Response

• Alan Perelson, Ruy Ribeiro – Modeling of infection and immune response
• Bill Hlavacek – Modeling of signaling and metabolic networks
• Chang-Shung Tung – Modeling of structure and interaction of virulence factors
• Jim Freyer – Tissue modeling and host-pathogen interaction studies

Disease Surveillance and Management

• Mac Hyman – Mathematical modeling for predicting the spread of diseases
• Kristin Omberg – Biodetection systems engineering
• John Ambrosiano – Analytical approaches for food security
• Helen Cui – Biothreat nonproliferation
• Scott White – Classified computing for bio-security
• Jeanne Fair – Avian immunology and host range

Bioinformatics

• Murray Wolinsky – Nucleic acid signature and assay design and analysis for biothreat detection, forensics, and diagnostics
• Judith Cohn – Integration of biological databases, and high throughput computational analysis
• Carla Kuiken – Viral evolution, biological database and tool development
• Ilya Nemenman – Genome–scale analysis and reverse- engineering cellular interaction networks

Bio-surveillance

• Babs Marrone – Bioforensics
• Norm Doggett – Biological assay development for detection and surveillance
• Hong Cai – Global surveillance of avian influenza virus
• Farzaneh Jebrail – Timed-release micro-encapsulation as a delivery vehicle

Vaccines and Therapeutics

• Bette Korber, Tanmoy Bhattacharya – Evolutionary biology and vaccine design
• Alan Lapedes – Antigenic, genetic, and structural characterizations of HIV-1 neutralization data
• Alan Perelson, Ruy Ribeiro – Understanding dynamics of viral infections
• S. Gnanakaran – Modeling of sequence-structure-function correlation
• Kevin Sanbonmatsu –Mechanism of bacterial riboswitches and potential applications in environmental sensing and antimicrobial therapy

Genome-Scale Measurements and Analyses

• Cliff Unkefer – Systems biology approach toward enzyme and microbial engineering
• Cheryl Kuske – Next-generation genomics
• Rich Okinaka – Whole genome sequencing: identification of new Bacillus anthracis lineage
• Srinivas Iyer – Mass spectrometry and proteomics at the Health Research Lab
• Pat Unkefer – Metabolomics
• Chang Kim – High throughput ligand analysis of genomic proteins for targeting

Protein Science and Engineering

• Geoff Waldo – GFP -based tools for protein analysis and detection
• Andrew Bradbury – Antibodies and other affinity reagents; use in detection, research and study of immune response
• Ben McMahon – Mechanistic interpretation of evolutionary analysis of RNA polymerase complex
• Mike Wall – Computational prediction of protein function using dynamics perturbation analysis
• Hristo Djidjev – Identification of functional modules in protein-protein interaction networks
• Hans Frauenfelder – Modeling protein dynamics

Detection and Diagnosis

• Basil Swanson – Next-generation biosensors
• Rob Cary – Field-deployable diagnostic systems and their application to applied genomics of citrus
• Jim Werner – Ultra-sensitive bioanalytical methods
• Steve Doorn – Raman fingerprints as multiplexing route for bioanalytical applications
• Steve Graves – Low-cost, portable flow cytometry for diagnosis and detection

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